Polyglutamic Acid
HumectantAnti-agingNaturalAlso known as: PGA, Gamma-Polyglutamic Acid
A fermentation-derived humectant that holds 4-5 times more water than hyaluronic acid. Also inhibits hyaluronidase to preserve skin's natural HA.
Routine placement
Serum · AM & PM
Time to results
Immediate hydration boost; 2-4 weeks for sustained improvement
Superior hydration to HA, inhibits HA breakdown, smooths skin, non-sticky feel, plumps fine lines.
Apply in serum form before moisturizer. Can be used morning and evening.
Studies show higher water-holding capacity than HA. Inhibits hyaluronidase enzyme, preserving the skin's own hyaluronic acid.
Cautions
Well tolerated. Non-irritating. Larger molecule stays on skin surface for a film-forming hydrating effect.
What does Polyglutamic Acid do for skin?
Polyglutamic Acid is used in skincare primarily as a humectant ingredient. Its effects depend on concentration and formulation. Check the benefits section above for specific details.
Is Polyglutamic Acid safe for sensitive skin?
Polyglutamic Acid is generally well-tolerated, but sensitivity varies by individual. Start with a patch test if you have reactive skin, and introduce gradually into your routine.
Can I use Polyglutamic Acid every day?
For most skin types, daily use is appropriate at standard concentrations. If you experience any irritation, reduce frequency to every other day.
Does your skincare contain Polyglutamic Acid?
Paste your product's ingredient list to check, or create your Skinularity ID for a full routine.
Find Polyglutamic Acid products
Browse skincare products containing Polyglutamic Acid.
Related to Polyglutamic Acid
A versatile form of Vitamin B3 that strengthens the skin barrier, reduces pore appearance, controls oil production, and addresses multiple skin concerns.
A gentle alpha hydroxy acid derived from milk. Larger molecular size than glycolic acid means slower, more gentle penetration. Also has humectant properties.
The provitamin form of Vitamin B5 that deeply hydrates and helps repair the skin barrier. Converts to pantothenic acid in the skin.
The acid form of panthenol (provitamin B5). Supports skin barrier function, wound healing, and hydration.
Copper peptides, most commonly represented by the tripeptide-copper complex GHK-Cu, are small protein fragments bound to copper ions that occur naturally in human plasma, saliva, and urine. GHK-Cu plays a fundamental role in tissue remodeling by stimulating the synthesis of collagen, elastin, glycosaminoglycans, and other components of the extracellular matrix. In dermatology, copper peptides have attracted significant attention for their dual capacity to promote wound healing while simultaneously reducing the appearance of aging skin. The copper ion serves as a cofactor for lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin fibers, while the GHK peptide sequence itself modulates gene expression related to tissue repair and anti-inflammatory pathways.