Palmitoyl Pentapeptide-4
PeptideAnti-agingAlso known as: Matrixyl, Pal-KTTKS
A collagen-stimulating peptide that mimics the pro-collagen I fragment. The original Matrixyl peptide with strong clinical data.
Routine placement
Serum · AM & PM
Time to results
4-8 weeks for firmer feel; 12+ weeks for wrinkle reduction
Stimulates collagen I, III, and IV production, reduces wrinkle depth and volume, improves skin texture.
Apply in serum or cream form. Use morning and evening for best results.
One of the most clinically studied cosmetic peptides. Double-blind studies show significant reduction in wrinkle depth comparable to retinol but without irritation.
What does Palmitoyl Pentapeptide-4 do for skin?
Palmitoyl Pentapeptide-4 is used in skincare primarily as a peptide ingredient. Its effects depend on concentration and formulation. Check the benefits section above for specific details.
Is Palmitoyl Pentapeptide-4 safe for sensitive skin?
Palmitoyl Pentapeptide-4 is generally well-tolerated, but sensitivity varies by individual. Start with a patch test if you have reactive skin, and introduce gradually into your routine.
Can I use Palmitoyl Pentapeptide-4 every day?
For most skin types, daily use is appropriate at standard concentrations. If you experience any irritation, reduce frequency to every other day.
Does your skincare contain Palmitoyl Pentapeptide-4?
Paste your product's ingredient list to check, or create your Skinularity ID for a full routine.
Find Palmitoyl Pentapeptide-4 products
Browse skincare products containing Palmitoyl Pentapeptide-4.
Related to Palmitoyl Pentapeptide-4
Copper peptides, most commonly represented by the tripeptide-copper complex GHK-Cu, are small protein fragments bound to copper ions that occur naturally in human plasma, saliva, and urine. GHK-Cu plays a fundamental role in tissue remodeling by stimulating the synthesis of collagen, elastin, glycosaminoglycans, and other components of the extracellular matrix. In dermatology, copper peptides have attracted significant attention for their dual capacity to promote wound healing while simultaneously reducing the appearance of aging skin. The copper ion serves as a cofactor for lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin fibers, while the GHK peptide sequence itself modulates gene expression related to tissue repair and anti-inflammatory pathways.
Pomegranate extract is derived from the fruit, peel, and seeds of Punica granatum, a plant with a long history of medicinal use across multiple traditional medicine systems. The extract is exceptionally rich in ellagitannins (particularly punicalagin), ellagic acid, anthocyanins, flavonoids, and punicic acid, a conjugated linolenic acid with potent anti-inflammatory properties. In skincare, pomegranate extract provides multi-pathway antioxidant protection that addresses both lipid peroxidation and protein oxidation. Its polyphenols have been shown to inhibit UVB-induced MMP-1 expression, protecting dermal collagen from photodegradation. Punicalagin, the predominant ellagitannin in pomegranate, is one of the highest molecular weight polyphenols found in nature and is hydrolyzed in the skin to release ellagic acid, which further contributes to tyrosinase inhibition and anti-melanogenic activity.
A naturally occurring antioxidant in the body that decreases with age. Helps energize skin cells and protect against oxidative damage.
An anti-inflammatory peptide that reduces IL-6 secretion, helping to prevent chronic inflammation-driven skin aging (inflammaging).
An extract from French maritime pine bark rich in procyanidins. A potent antioxidant with anti-inflammatory and collagen-protective properties.